Volokhina, Elena B.; van de Kar, Nicole C.A.J.; Bergseth, Grethe; van der Velden, Thea J.A.M.; Westra, Dineke; Wetzels, Jack F.M.; van den Heuvel, Lambertus P.; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-23)
Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated
with high costs. Complement inhibition monitoring in these patients has not been standardized. In this
study we evaluated novel functional assays for application in routine follow-up.
We documented that the Wieslab® complement screen assay showed a sensitivity of 1–2% of C5 activity ...